French Biotech Receives an Award to Develop a Novel Cystic Fibrosis Antibiotic

https://labiotech.eu/antabio-carb-x-cystic-fibrosis/

CARB-X has awarded $8.9M (€7.6M) to Antabio for the development of a new antibiotic against resistant Pseudomonas infections in cystic fibrosis patients.

Antabio is a French company developing new antibiotics to fight the rapidly Continue reading French Biotech Receives an Award to Develop a Novel Cystic Fibrosis Antibiotic

New Drug Improves Effectiveness of Antibiotics against Drug-resistant Bacteria

Synspira’s Novel Glycopolymer Improves Effectiveness of Antibiotics Against Drug-resistant Bacteria Associated with Cystic Fibrosis

Synspira, a privately held company developing a new class of inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease, Continue reading New Drug Improves Effectiveness of Antibiotics against Drug-resistant Bacteria

UBC research uses genomics to help cystic fibrosis patients

http://www.metronews.ca/news/vancouver/2017/03/29/ubc-uses-genomics-to-help-cystic-fibrosis-patients–.html

The hope is that DNA sequencing burkholderia bacteria that cause life-threatening infections in cystic fibrosis patients will lead to cheaper treatment options. Continue reading UBC research uses genomics to help cystic fibrosis patients

New antibiotic could treat superbugs

http://www.medicalnewstoday.com/releases/315898.php

New antibiotic from bacteria found on Kenyan ant could help beat MRSA

A new antibiotic, produced by bacteria found on a species of African ant, is very potent against antibiotic-resistant ‘superbugs’ like MRSAaccording to scientists.

Researchers at the University of East Anglia (UEA) and the John Innes Centre (JIC) discovered a new member of the Streptomyces bacteria family, isolated from the African fungus-growing plant-ant Tetraponera penzigi. They have named the new species Streptomyces formicae and the antibiotics formicamycins, after the Latin formica, meaning ant.

Lab tests have shown these new antibiotics are effective against methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococci (VRE), bacteria which are resistant to a number of common antibiotics and can cause life-threatening infections.

Almost all of the antibiotics currently in clinical use come from a group of bacteria called actinomycetes that were isolated from soil between 40-80 years ago, the ‘golden age’ of antibiotic discovery. Inappropriate use of these antibiotics since then has led to widespread antimicrobial resistance (AMR), where disease-causing bacteria and fungi have become resistant to one or more antibiotics.

Prof Matt Hutchings from UEA said: “We have been exploring the chemical ecology of protective symbioses formed between antibiotic-producing bacteria and fungus-growing insects to better understand how these associations are formed and explore them as a new source of anti-infective drugs.

“Kenyan plant-ants live in symbiosis with thorny acacia trees. They live and breed in domatia – which are hollowed out structures which the plant evolved to house them – and grow fungus in them for food. In return, they protect the plants from large herbivores including elephants, which won’t eat plants covered in ants.”

The team isolated a number of actinomycete bacterial strains from the acacia plant housing the ants, selecting a number for genome sequencing. One particular strain caught their attention, and the antibiotic compounds produced from it showed promising activity in early tests against other disease-causing bacteria.

Prof Hutchings said: “We tested formicamycins against clinical isolates of MRSA and vancomycin-resistant Enteroccocus faecium (VRE) and found that they are very potent inhibitors of these organisms.”

To test this further, they repeated the tests by growing the strains for 20 generations in very low, sub-inhibitory concentrations of formicamycins and found no sign that the test strains acquired spontaneous higher level resistance to the new antibiotics.

Prof Wilkinson from JIC said: “Our findings highlight the importance of searching as-yet under-explored environments, which, when combined with recent advances in genome sequencing and editing, enables the discovery of new species making natural product antibiotics which could prove invaluable in the fight against AMR.”

Article: Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants, Zhiwei Qin, John T Munnoch, Rebecca Devine, Neil A Holmes, Ryan Seipke, Karl A Wilkinson, Barrie Wilkinson and Matthew Hutchings , Chemical Science, doi: 10.1039/C6SC04265A, published online 13 February 2017.

My Wish List for the New Year By Gunnar Esiason

I’m not naïve enough to think that I’m going to wake up tomorrow and find that my life is moving forward with cystic fibrosis in the rearview mirror.

We’re still a little bit away from that moment, but that doesn’t mean I don’t have high expectations for treatment development. Continue reading My Wish List for the New Year By Gunnar Esiason

Making it Matter Ep. 19

Making it Matter Ep. 19: Psychological Impact of Hospital Stays

Julia and I take a question from a listener on Twitter for this episode of Making it Matter:

@Ruth_Hochberg: I’d be interested to learn about coping & psychosocial effects of long term hospital stays on Making It Matter! Continue reading Making it Matter Ep. 19

New Cystic Fibrosis device to reduce antibiotic usage

http://www.medicalnewstoday.com/releases/314410.php

A medical device for Cystic Fibrosis (CF) sufferers which lessens their exposure to infections resulting in fewer doctors’ visits, reduced antibiotic usage and shorter hospital stays, is expected to be market ready within two Continue reading New Cystic Fibrosis device to reduce antibiotic usage

BEF Presents Inspirational Documentary, Up For Air, About 60-year-old CF Ambassador

We are proud to support Up For Air, a documentary about BEF ambassador and 60-year-old pole-vaulting coach living with CF, Jerry Cahill.
https://www.youtube.com/watch?v=5FhWPmFHcr0

The film, directed and produced by Artem Agafonov, was shot over a period of Continue reading BEF Presents Inspirational Documentary, Up For Air, About 60-year-old CF Ambassador

FDA MedWatch – Fluoroquinolone Antibacterial Drugs for Systemic Use: Drug Safety Communication – Warnings Updated Due to Disabling Side Effects

https://mail.google.com/mail/u/0/?shva=1#inbox/156280eeebf12efe

ISSUE: FDA approved changes to the labels of fluoroquinolone antibacterial drugs for systemic use (i.e., taken by mouth or by injection). These medicines are associated with disabling and potentially permanent side effects of the tendons, Continue reading FDA MedWatch – Fluoroquinolone Antibacterial Drugs for Systemic Use: Drug Safety Communication – Warnings Updated Due to Disabling Side Effects

OWN IT: Please Don’t Ever Complain

Like many Americans this past weekend, I found my way to somewhere warm with friends and family.

Unlike many Americans, though, I found myself in the middle of a two-week tune up. Continue reading OWN IT: Please Don’t Ever Complain